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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cb5c6f88f9c91276b2d7b85659459867e092f492d8d054dba656017b0c66456c' 
  AND token = '4ncKwyQQTf1rglO/qOqa379daDTta8J/2dMTwrELcSA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}