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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9ddf1275cc04ffb3aec64734f55e2d493b7571392d303188fc9e5e3f2e9009a4' 
  AND token = 'tl7W8k6rD0HTqrIh0gQHtDa3c3MGjnVkIkrx1tSzO0g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}