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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2fd1a5814ed07b1380cab74ef6b8ae821c368508440d071b6f1c46f7f7e487c0' 
  AND token = 'eXcr+VbwaeacVYxPZwRpYEkYq+9nE6PSb/Kt15hTHno=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}