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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21db78ce37a5368d3d37e2b6e1620ed39c6584cd5209584e1b9ac05e8493a56b' 
  AND token = 'YXfoaHaKVBCINppTPS/f6uTOTbA2MEEnMlSk5+ULZl0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}