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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd825f062159fd2a9be5aff81b9900e6b89ba98119f3d9c8598a29c8ebe1e1345' 
  AND token = 'DcAdpBYAAcd0zLc6nvae+6TrgsaTSqm/OqSxvdh3Cb4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}