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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ce82f893e98b4cd308087d11117fc2a2b5f26777d03101611f9cc2aafad05d50' 
  AND token = 'oV8IRqtmYoIWeMiTT9l/77KaDOnYmqM9UZ5dnTTQt30=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}