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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '425adbba0929c78befb13e1b2e0117e0be8ae15606ad5732858f2b7f3bdb2a36' 
  AND token = 'SKYC1iJh/3ZOdvynQMJIBdcRuIWfFaIB2t6zPwNCEkA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}