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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2d85101dda4c158837ed6585b56a57b61ee5dfe31f746892d9a2016e6f66eee6' 
  AND token = 'QzUiQ2HS/8y1PH+GcAL8SgBKWmzVyJs5OhdDUcNrMnA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}