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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '729e701078d03669f573288e711792f0e5e165fdebd107831a2dbdeb088bebd6' 
  AND token = 'Z6xM27O/cAid4NBeCDVSArWAABSLfSAju+WJENKBfSw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}