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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65c6e743db651f93a51397a38af566093a59f60670e2397d860312103a87bb90' 
  AND token = 'uP5o9+3Re8JU77tcAWSoW+Y8YHTInfZsnyqp2oO25dI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}