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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4660a5a4470c6a3c123d57f14ede080ef0363fbe69c50474d980a2e2361c3fe1' 
  AND token = 'qtuAozu58uXAeSyVoIlsNf83L1sXtBOatYS3nLHpB74=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}