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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '480fd624fd18a58482e22cde414df7131420ab94072a9a4f7d1e17dc541a92f7' 
  AND token = 'TX40wzCuZuK//NgwqH4N7r9AQEKkZWtFD9g+GlcNaVM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}