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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '222d1ca44f078c770059ec7e0075c712fdcc4cd4ac045e54557ab7e48b79230f' 
  AND token = 'wxXuYjpQkitTDqxuRmWAQ9YpermgelJno3HQO9ECQ3A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}