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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f2c8f10f72f5036a9518aee8642a0c0969d10543121b3455df8b1f9c02a18951' 
  AND token = '+TEYFjX55IfK5+vh+xQyHjpfLN77xFMVYjC71biHYxw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}