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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a725e0e76289307a6ccca8ac9b3c18c69b8e535fea749feb51f5219494fe5fbe' 
  AND token = 'xJKhJ2IU4/hQsCjaGO0I+HCCY8HG68oXRiGTYqCbCD4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}