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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '50022cdb1065b283c2c0779c44c729c9a9010e1737df8670b0347491350f5a0d' 
  AND token = 'tUdGSSToWP9ptGiTw0PCDRTzMSwV/c34u1w9uSmfJW0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}