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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e66e1c2004b471a833094564818c067e45d4d15a27852d5436b41e45bd1b1aad' 
  AND token = 'CE1HtC3to4Xo+x0cyxiVCJdIxG/2CV2H1KG9B7R2aU0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}