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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f6ac21b3385b30c2605ec6e2208e113761124e2152d63c0fafccf1224a679f6e' 
  AND token = 'JqwHpgVjOIZFTi3Tn//d5I6TlFMOhPnPTD1D+kb9K4g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}