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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3c1ef7e8ddf2808e67c237424f78f497b53a810261a8b3d33e3ecc6699425ec8' 
  AND token = 'GiR7/oo1dYG/AWzdPfgmSVeHTFL+K4vCGmSC+C0dCiY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}