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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '975226b6f4676fcf6014eb7ea747c94aa9030323ce408fa2c753989c096c4166' 
  AND token = 'k2u6oSIZ1eh1W9Fzis0CSH84UMOAMV5GMhQ7E+AgMEM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}