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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7eaca8d32ef7969f906146eb28a3a46e8b7227fcd9a12e0290934226bd494af5' 
  AND token = 'UAGrxJ2Kft5QHWNL/y+MvocIBL9l0IDcqKDB47qjQrM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}