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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '559c598f81564c1d19f175f37aa0809d83ac5b48650f70e2f2cf446aa36461a5' 
  AND token = 'XwUCd43MWf8uver11k31jKau6snf37ndRKZcDkPS0cc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}