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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9ca86fdb2b995b0d68a629b399fc3da8bda11a2222d63bd4b8814036ecf17f54' 
  AND token = 'CTZLvlaK8eoBseN/9irw6K5zfyUGR3Iua1CpvAhzmDk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}