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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6ac1282043dfff8cd6150c6e62cd4fe852429ed567931d2d9fdf67d16f2f5b50' 
  AND token = 'RIY7M+vIovuhQ2Dx1NdLNw4Yw+SChgIGaX8UenSblAk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}