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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '14940b4040f8232d5307720dd20180b3869bc0a06927cc00f41caab883332ec1' 
  AND token = 'oZb2naR1Vx/s/KRxnQ3HgR+hFu3f8vdn1+HWTO45pIY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}