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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f133fc7cdd13b17cdc6e21c87743e79d240a2b61cd810798130d341e09085ebe' 
  AND token = 'QysDME0SonlX+OYefgGi696xk132wY4BiF3nkPAj0ps=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}