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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'dddd308d3fcb8abc9688199ff1a223e32a66d6e4f2b4ed089f5e53a0f32013de' 
  AND token = 'M1q1DOIekidz1fOfux6xUBjfUAlsBXLWyHXJ0ZaHIJs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}