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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a2d2ac02f40189f485a40394828e65dd2f61b072df00c105a8925c5d3c171e49' 
  AND token = 'DbY+NH8M3rCxG1fjWqWZPqht0RLPYrG/U1DutDLLHzQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}