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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '515d01552630590837ec90b9e184b39a35bf512eedb98b3f59569b000f72440a' 
  AND token = 'PtM2tNsCYEUymNYmaCQCFz5brulVtO0cfEnytiYCDko=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}