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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0221f0e9a16e336865e753bdc069d72d894aff7608aee5b593d9a76b1ab9a951' 
  AND token = '+tXnlOuVj6sRcvuDVMigLHKNlXs1a6w18wwaaM9FdKo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}