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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c2f1697b429b866b56ddeb37e730c90c1b2001043b2bcdc7024c6b21864a1790' 
  AND token = 'fQ7u51OV4Bdvz6XncmYsQX+iaoG8ZiZ3dnei1+0RjtM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}