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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '39862874bdf39e9857f59e243a83e48228be4a04ed257586079ea7b0718be085' 
  AND token = 'IOQu4j+6338itXAqVMtkdE5hKXFkPvktQMKzpn1oCIo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}