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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6f1d6e3068cffd51c662192f09e75a49eff67be405e3fa36bc1a023a2079e6b0' 
  AND token = 'o0jBd90L9LQH9qYPd6c8zRsE5CQ+Yz5WK5bOZw2fLV8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}