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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '443b8f251b97d80f7cc66402adccdb4f3a89ad9e37a8b1b3cf046a440b626de5' 
  AND token = 'HLYneLPoInGY4Q1RUhr/8xfeaCb8PVUAiqyr72IMdFY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}