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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b379583d7e9a51fbb7b44a387803e001e664c0d710f5979b830ab2a76a66c0af' 
  AND token = 'UJuz+pmeVR5yMA1kUds0cDI8demOfSFI5xG6rJBpGj0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}