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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a377b5ab15f21e37e5b7d2935d3f28a37abbd160a607a3332d448c2c31dafad5' 
  AND token = 'Z70N/zQpXxdxSttVim0NyfUvGwdqT2cIYSsBYIfcY8Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}