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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '33870032e4c626549293ccc0d081922ac937d67cee4a2b3edca9cc83f0d5a661' 
  AND token = '8bK4PAPOZ+ToRPzFIHD76BqDZYHe/f4SxBZrPXDd/p8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}