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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '428686e2ff2cc2ccc3deb00466eb26b1d376f6c796ab1529d9d01d6d2b36efe0' 
  AND token = 'OR5gitGkMQpThJTAmdzoVfQ+Lp7VRJXmG/w4sw5dt0I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}