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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0ea486585503f0f7cc4c8f33c3a25a00447577c1eeed61a1765acbadc42d8546' 
  AND token = 'AwshCFqlF7IKs2yD/RB9mfYynfiF5SumWfnJwVbu/A4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}