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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e5c18f418336a2c52c9c7dc149bb849aac7d0f272ddf68562b04b7945e9a549f' 
  AND token = 'eVhYOtGkWhOQeB+As4PFWiyRjMMiM2U8YaekcNfIQOE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}