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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22edd42d92f918548b595926247345be240a7c8c5c3cdc2f15e309eb469cec2c' 
  AND token = 'Al5RZ+fi81u0IArA3INNMLJNbVC3PIDXfHUBTtvTA7g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}