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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c1337f1bcfd470983b5e356709fec6ea3c55eb39fb9acea8c6361604c94e46da' 
  AND token = 'GdpUbSHfA/fNRC7PMl+GxtME3lZwZTtyA+0sb1Y8Oww=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}