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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '06c2232e79c7e4ca77a21428c27ee0218f4de85e85cb1f5f5249edd5bf9e8015' 
  AND token = 'O0Y3CqjRVulzYbQrfTjcK4VCpdiB7OuUQNBVflD9dR0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}