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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ae2d4901a99d20c194a2a5fdf1298bf40fc8b0a5305f04881ebbeeb889258427' 
  AND token = '15q1X0+ZqAdELhj15/coIkPYXLxz3ENud+z2j7HERPE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}