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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '016f5a63121546fe2597791e9af4cbedcae37a136d4a3b395f94ceb32d9357c3' 
  AND token = 'ipiDn8lM2/aKuVAX4MRjJgGQ3UaWre7vJx2NErIbrm8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}