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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f49a9586aef133f44a72b3107c5fd5a5193d397e7bf60ecb7c3d4017b16fe897' 
  AND token = '1EXF3VsvY0SSUxxNPysWHmuadTZmTuD/XCzeb+3nSa4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}