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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '93919141587a795dca9df363e4df0737fdda166d3d337dcd0a47d828eaa3df72' 
  AND token = 'O6Rm+qG7xIKhH2iGW/MIDyPTVKsLmcm9qU1eMSq63C8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}