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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9ece451550d34db9bd8cb7c1a91a331c0f0c9000ca5468b8b778bc08265ead27' 
  AND token = 'ZZmWBHKTbMDWCou++acWGYzkiVjnKUYMLt7QvUOe8d8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}