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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7e4a8bbc27fd20a4b17c39a1648b8cbefaad86a457f78935c97cf1b642401df4' 
  AND token = 'UXRYPuIK+e/oPQR3P6VYUuGO6k0lmGmM23WoVlu0dQc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}