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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '004b4c4bce2809b8c1e1fde684c3627dd4d0d1888ec8e8fbfbb4423358ead954' 
  AND token = 'TTo2A8BZXaAguRLnhC+wnyBqx8CmTlS3Mh73mIp9gxI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}